Although the occurrence of mold in the home raises concerns for a number of reasons, the effect it can have on health is often downplayed. In reality, research suggests that the health risks associated with mold exposure can be varied and as far-reaching as asthma development in children. However, the presence of mold itself is often not as problematic as the spores it produces and the mycotoxins it releases. In addition to exposure from mold in the home, mold spores and mycotoxins may also be present in foods. This article highlights the negative health implications associated with mold exposure, and how to regain health when mold toxicity is suspected. 

Mold, a type of fungi, develops in the presence of water or moisture, especially when the area is poorly ventilated or lacks natural sunlight. In your home, the source of water (or moisture) may come from leaks, rising damp and condensation. Other factors play a role, including humidity levels, with high humidity a cause of condensation, and reduced ventilation, which may occur in bathrooms. 

While structures, such as walls, and plumbing are often considered to be the primary sites for mold growth in the home, the release of airborne mold spores allows this opportunistic fungi the potential to spread to furnishings, carpets and clothes. 

In terms of dietary sources of mold spores and mycotoxins, foods can be affected both before and during harvest, or whilst being transported and stored. Foods most likely affected by mold include grains, nuts and seeds, spices, fruits, wine and coffee beans, which may be either exposed to damp and humid conditions or cross-contaminated. 

Mold is a health concern for those with mold allergy, with symptoms triggered from exposure to either mold or mold spores. Research suggests that mycotoxins released by mold spores may also trigger symptoms in the absence of allergies, which is often referred to as mold toxicity, or mold reactivity. (1) Mold toxicity may not arise from exposure to mold alone; rather, it could be a consequence of over-exposure to multiple toxins, which collectively place a greater burden on the body.

Mold spores and mycotoxins are generally associated with inflammatory responses and immune suppression, but genes also influence how individuals react. Specifically, HLA-DR genes may inhibit an appropriate immune reaction to mold, leading to sensitivity in some. (2, 3) This may explain why one member of the same household can be affected by the presence of mold while another doesn’t experience any reaction. 

Similarly, mold spores and mycotoxins can affect health in many ways, making it difficult to determine whether mold exposure is the symptom trigger. Exposure has been linked to respiratory symptoms, including allergic rhinitis, shortness of breath, respiratory infections and asthma. (2) Studies suggest that in children, mold exposure in the home may even lead to the development of asthma. (4) Potential symptoms also include eczema, hypersensitivity pneumonitis, renal toxicity, fatigue, headaches, insomnia, anxiety, gastrointestinal problems and decreased reproductive capacity. (2, 5, 6) 

Several species of mycotoxins often found in food are considered particularly hazardous to health. These include aflatoxins, ochratoxin A, fumonisins, tricothecenes and zearalenone. Aflatoxins are considered to be carcinogenic, ochratoxin A is associated with oxidative DNA damage, and animal studies suggest that fumonisin B1 exposure may impair the formation of myelin in brain cells. (7, 8) Other negative associations with exposure to these mycotoxins include neural tube defects, depression and neurotoxicity. (9) 

Although guidelines exist to protect consumers from mycotoxin exposure in the diet, for those affected by mold and mycotoxin exposure, take additional precautions by scanning and avoiding food with visible signs of mycotoxin content, including the presence of mold, discoloration, or a shriveled appearance. Ensure food is purchased as fresh as possible and stored in a cool and dry location.

Removing mold spores from your home may mean physically removing and replacing damaged materials, while simultaneously dealing with the source of the problem. Not all materials that have been affected by mold actually need to be removed though. Porous materials (wallpaper, plaster and wood) may provide adequate nutrition for mold to grow and are best replaced, whereas non-porous materials (metal, glass and plastic) can be cleaned, as long as the source of moisture is also addressed.

As water or moisture is required for mold, identifying and removing the source may prevent further growth. However, without removing the mold itself, reducing moisture may trigger the mold to produce additional spores as a survival mechanism. Similarly, removing mold by removing or cleaning affected materials alone is not enough to prevent new growth if the original moisture source is still present. 

Due to the airborne nature of mold spores, which are not always visible, regular cleaning of other surfaces is also necessary to fully eliminate spores. Removing mold has been shown to reduce symptoms of asthma and rhinitis, and also reduce the use of medications for these conditions. (10)  

Improving air supply in poorly ventilated rooms may also help to prevent mold growth. Consider opening doors and windows daily to help circulate air, drying wet surfaces in poorly ventilated rooms, thoroughly drying damp towels and mats, and using a dehumidifier to keep humidity levels low. Mold growth will occur at lower levels of humidity during higher temperatures, in comparison to a cooler room with higher humidity levels. (11) Avoid long hot showers or baths which may increase both the humidity and temperature levels, thus providing an optimal environment for mold growth. 

Studies have found mycotoxins in sweat, suggesting that sweating may help to remove them from the body. Sweating can be induced with exercise or dry saunas. (6)

Studies suggest that mycotoxins disrupt the outer layer of the intestines. Healthy gut microbiota may support the elimination of mycotoxins from the gut. (12) A multi-strain probiotic will support the restoration of gut microbiota.

Mycotoxin exposure has been linked to increased oxidative damage to cells. Increasing your dietary intake of antioxidants from fresh and brightly colored fruits and vegetables will provide additional antioxidant support to cells. Reduced glutathione levels are often observed by clinicians supporting those exposed to water-damaged buildings, with supplementation of N-Acetyl cysteine, a precursor to glutathione, showing promise in clinical practice. (6)

1. Edmondson, D. A., Nordness, M. E., Zacharisen, M. C., Kurup, V. P. & Fink, J. N. (2005) 'Allergy and "toxic mold syndrome".' Ann. Allergy Asthma Immunol, 94(2): 234–239. doi: 10.1016/S1081-1206(10)61301-4 

2. Mendell, M. J., Mirer, A. G., Cheung, K., Tong, M., & Douwes, J. (2011). ‘Respiratory and Allergic Health Effects of Dampness, Mold, and Dampness-Related Agents: A Review of the Epidemiologic Evidence’. Environmental Health Perspectives 119:6 CID: https://doi.org/10.1289/ehp.1002410 

3. Valtonen V. (2017). ‘Clinical Diagnosis of the Dampness and Mold Hypersensitivity Syndrome: Review of the Literature and Suggested Diagnostic Criteria’. Frontiers in immunology, 8, 951. doi:10.3389/fimmu.2017.00951 

4. Caillaud, D., Leynaert, B., Keirsbulck, M., & Nadif, R. (2018). ‘Indoor mould exposure, asthma and rhinitis: findings from systematic reviews and recent longitudinal studies,’ European Respiratory Review, 15;27(148). pii: 170137. Doi: 10.1183/16000617.0137-2017. 

5. Bush, R. K., et al. (2006). ‘The medical effects of mold exposure’. Journal of Allergy and Clinical Immunology, 117, (2), pp. 326 - 333. 

6. Hope J. (2013). ‘A review of the mechanism of injury and treatment approaches for illness resulting from exposure to water-damaged buildings, mold, and mycotoxins.’ The Scientific World Journal, 2013, 767482. doi:10.1155/2013/767482 

7. Palma, N., Cinelli, S., Sapora, O., Wilson, S. H., & Dogliotti, E. (2007). ‘Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress’. Chemical research in toxicology, 20(7), 1031–1037. doi:10.1021/tx700027j 

8. Monnet-Tschudi F., Zurich MG, Sorg O, Matthieu JM, Honegger P, Schilter B. (1999). ‘The naturally occurring food mycotoxin fumonisin B1 impairs myelin formation in aggregating brain cell culture.’ Neurotoxicology, 20(1):41-8. 

9. Doi, K., & Uetsuka, K. (2011). ‘Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways’. International journal of molecular sciences, 12(8), 5213–5237. doi:10.3390/ijms12085213 

10. Burr, M. L., Matthews, I. P., Arthur, R. A., Watson, H. L., Gregory, C. J., Dunstan, F. D., & Palmer, S. R. (2007). ‘Effects on patients with asthma of eradicating visible indoor mould: a randomised controlled trial.’ Thorax, 62(9), 767–772. doi:10.1136/thx.2006.070847 

11. He, Y., Luo, Q., Ge, P., Chen, G. & Wang, H. (2018). ‘Review on Mould Contamination and Hygrothermal Effect in Indoor Environment’. Journal of Environmental Protection, 9, 100-110. https://doi.org/10.4236/jep.2018.92008 

12. Liew W-P-P and Mohd-Redzwan S (2018) ‘Mycotoxin: Its Impact on Gut Health and Microbiota’. Frontiers in Cellular and Infectionary Microbiology, 8:60. doi: 10.3389/fcimb.2018.00060